Immunohistochemistry Kits and Reagents
Medchemexpress LLC Plasmalemma vesicle-associated protein (PLVAP), human recombinant (HEK293, His tag) | ≥95.0% | 100UG
Recombinant human plasmalemma vesicle-associated protein (PLVAP) is supplied as a lyophilized, HEK293-expressed His-tagged protein for research on endothelial barrier function and microvascular permeability. The material is provided with low endotoxin and guidance for reconstitution and storage to support biochemical and cell-based studies.
- Species: human.
- Source: HEK293 expression system.
- Tag: His tag for purification.
- Purity: ≥95.0% as determined by Tris-Bis PAGE.
- Molecular weight: 50-70 kDa.
- Formulation: lyophilized from PBS with 200 mM l-arginine and 8% trehalose.
- Endotoxin: <1 EU/μg.
- Storage: store lyophilized at -20°C; aliquot and freeze after reconstitution.
ABclonal Technology Phospho-SMO-S616 Rabbit pAb
The protein encoded by this gene is a G protein-coupled receptor that interacts with the patched protein, a receptor for hedgehog proteins. The encoded protein tranduces signals to other proteins after activation by a hedgehog protein/patched protein complex.
ABclonal Technology S100P Rabbit pAb
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21, however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer.
Medchemexpress LLC Discoidin domain receptor 1 (DDR1), rat recombinant protein (HEK293, His-tag) | >95.0% | 500 UG
Recombinant rat discoidin domain receptor 1 (DDR1) expressed in HEK293 cells with a C-terminal His tag. This purified protein is designed for biochemical and cell-based studies of collagen-mediated signaling, matrix remodeling, and protein-protein interactions. Purity is reported as greater than 95% by reducing SDS-PAGE, and multiple size formats are available, including a 500 μg option.
- HEK293-expressed rat DDR1 with C-terminal His tag.
- Purity greater than 95% as determined by reducing SDS-PAGE.
- Available in multiple sizes, including a 500 μg format.
- Suitable for biochemical and cell-based assays.
- Useful for studying collagen-mediated signaling, matrix remodeling, and receptor interactions.
ABclonal Technology 488 Conjugated AIF1/IBA1
Enables actin filament binding activity and calcium ion binding activity Involved in several processes including Rac protein signal transduction actin filament organization and ruffle assembly Acts upstream of or within actin filament bundle assembly Located in several cellular components including actin filament phagocytic cup and ruffle membrane Is expressed in adrenal cortex central nervous system embryo mesenchyme and retina Human ortholog(s) of this gene implicated in type 1 diabetes mellitus Orthologous to human AIF1 (allograft inflammatory factor 1)
ABclonal Technology Phospho-p38 MAPK-T180/Y182
This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes including cell proliferation differentiation transcriptional regulation and development The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs) Alternative splicing results in multiple transcript variants [provided by RefSeq Mar 2014]
Revvity Health Sciences Inc AlphaLISA SureFire Ultra Human Total c-Myc Detection Kit, Control Lysate
AlphaLISA SureFire Ultra Human Total c-Myc Detection Kit, Control Lysate
Revvity Health Sciences Inc HTRF Human & Mouse Phospho-TDP-43 (Ser409) Detection Kit, Control Lysate
HTRF Human & Mouse Phospho-TDP-43 (Ser409) Detection Kit, Control Lysate
Cayman Chemical p38 MAPK InhIbItr VIII 10mg
An inhibitor of p38α (IC50 = 39 nM) and p38β MAP kinases with 82 and 93% inhibition, respectively, in a kinase assay (1 µM); selective for p38α and 38β, lacking activity at p38γ, p38δ, ERK1/2, and JNK1 at 1 µM; inhibits IL-1β, TNF-α, IL-6, IL-8, and IL-10, but not IFN-γ release from human peripheral blood mononuclear cells (IC50s = 30, 5, 17, 4, 10, and >1,000 nM, respectively); decreases EAr swelling in mouse models of allergic and chronic irritative contact dermatitis (0.5 mg/ear, topical)
ABclonal Technology WTAP Rabbit pAb
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms.
Biotium pS2 / pNR-2 / TFF1 (Estrogen-Regulated Protein) (TFF1/2969R), Biotin conjugate, 0.1mg/mL
This antibody recognizes a polypeptide of 6.5 kDa, identified as pS2 estrogen-regulated protein. Its epitope is localized between aa57-84 of human pS2 protein. pS2 is a trefoil peptide. Trefoil peptides are protease resistant molecules secreted throughout the gut that play a role in mucosal healing. These peptides contain three intra-chain disulfide bonds, forming the trefoil motif, or P-domain. pS2 is known to form dimers and this dimerization is thought to play a role in its protective and healing properties. About 60% of breast carcinomas are positive for pS2. Staining is cytoplasmic, often with localization to the Golgi apparatus. pS2 is shown to be localized in normal stomach mucosa, gastric fluid, goblet cells in the colon and small intestine, and in ulcerations of the gastrointestinal tract. Several studies have shown that pS2 is primarily expressed in estrogen receptor-positive breast tumors and it may define a subset of estrogen-dependent tumors that displays an increased
ABclonal Technology Phospho-PDK1/PDPK1-S241 Rabbit pAb
Enables 3-phosphoinositide-dependent protein kinase activity, phospholipase activator activity, and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway, regulation of protein kinase activity, and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection, cytosol, and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma.
Medchemexpress LLC DDR1 recombinant protein (rat, HEK293, C-His tag) | 98.0% | 100 UG
Recombinant rat discoidin domain receptor 1 (DDR1) produced in HEK293 cells and supplied as a C-terminal His-tagged, lyophilized protein for use in biochemical and cell-based assays, receptor-ligand studies, and antibody validation. It preserves mammalian post-translational modifications and is provided in multiple size options to suit different experimental scales.
- HEK293 expression preserves mammalian post-translational modifications.
- C-terminal His tag enables affinity purification and detection.
- High purity suitable for biochemical and antibody validation assays.
- Lyophilized format allows long-term storage and easy reconstitution.
- Multiple size options support small-scale and larger studies.
ABclonal Technology SYNPO Rabbit pAb
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the proteins associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).